Latest CKD Research Topics + Resources

Featured Recent Research Topics (2024–2025)

1. SGLT2 Inhibitors Beyond Diabetes
   Clinical trials (e.g., DAPA-CKD, EMPA-KIDNEY) show that SGLT2 inhibitors slow CKD progression even in non-diabetics.
   Key Medications: Dapagliflozin, Empagliflozin
2. Gut Microbiome and CKD
   Studies show imbalance in gut bacteria increases uremic toxins.
   Interventions: fiber-rich diets, probiotics, fecal transplants (early-stage research)
3. Low-Protein Diet + Ketoanalogues
   New interest in very low protein diets combined with ketoacid supplements to delay dialysis in Stage 4/5 CKD.
   Randomized trials underway in Europe and Asia.
4. Novel Biomarkers for Early Detection
   TNFR1, TNFR2, and KIM-1 outperform creatinine in predicting rapid decline.
   Goal: personalized kidney disease staging.
5. Plant-Based Diets and CKD Outcomes
   Observational studies link vegetarian diets with slower CKD progression and lower cardiovascular risk.
6. Potassium-Reducing Therapies
   Patiromer and sodium zirconium cyclosilicate (Lokelma) allow patients to continue RAAS inhibitors safely.
7. AI in Kidney Risk Prediction
   Machine learning models increasingly used to forecast progression, hospitalizations, and medication response.
8. CKD and COVID-19 Impact
   Long-term kidney complications after COVID-19 infection under review.
   Research on risk of acute kidney injury (AKI) leading to long-term CKD.

Top Resources for Ongoing CKD Research

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• Subscribe to JASN Alerts or Kidney International eTOC for monthly updates.
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• Ask your doctor about relevant clinical trials in your area (using ClinicalTrials.gov).
• Read KDIGO guidelines every few years for best practice standards.